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En el caso de que el donante no sea un familiar, se desaconseja el trasplante como opción inicial, reservándolo sólo para pacientes que no responden al tratamiento con TKI o que no toleran los TKI. La edad límite es más reducida que con los trasplantes de donante familiar y la condición general del paciente ha de ser buena para afrontar las posibles complicaciones del trasplante.
A modo de resumen, podemos decir que aquellos pacientes con LMC en los que no se consigue una respuesta hematológica o una buena respuesta citogenética y molecular tras uno o dos TKI, o que no toleren este tipo de tratamiento y tienen un donante compa¬tible, el alo-TPH es el tratamiento de elección.
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Sabías que…
El Día Mundial de la LMC se conmemora el 22 de septiembre porque el origen de la enfermedad procede del intercambio de material genético entre los cromosomas 22 y 9.
